Clinical studies of induction agents. V. The use of G.29.505 as an induction agent for a standard operation.

G.29.505 was used as a single dose induction agent (4 mg/kg) before nitrous oxide and oxygen with halothane or trichloroethylene for the operation of dilatation and curettage. The findings are compared with those of another series in which intermittent injections of G.29.505 supplemented the nitrous oxide. Rapid recovery resulted in a high incidence of coughing and hiccough during the introduction of both volatile agents. Hyoscine premedication increased the frequency of spontaneous muscle movements following the induction of anaesthesia. Halothane was followed by a very low incidence of emetic sequelae. G.29.505 cannot be used as a satisfactory substitute for an induction dose of thiopentone.